Universidad Peruana Cayetano Heredia

Screening transplant donors for HTLV-1 and -2

Screening transplant donors for HTLV-1 and -2

Gallo, R.C.; Willems, L.; Hasegawa, H.; Accolla, R.; Bangham, C.; Bazarbachi, A.; Bertazzoni, U.; De Freitas Carneiro-Proietti, A.B.; Cheng, H.; Chieco-Bianchi, L.; Ciminale, V.; Gessain, A.; Gotuzzo Herencia, José Eduardo; Hall, W.; Harford, J.; Hermine, O.; Jacobson, S.; Macchi, B.; Macpherson, C.; Mahieux, R.; Matsuoka, M.; McSweegan, E.; Murphy, E.L.; Péloponèse, J.-M.; Reis, J.; Simon, V.; Tagaya, Y.; Taylor, G.P.; Watanabe, T.; Yamano, Y.
URI: https://hdl.handle.net/20.500.12866/6534
Fecha: 2016

Resumen:

Human T-cell leukemia virus-1 (HTLV-1) is the first pathogenic human retrovirus discovered in 1980. HTLV-1 causes 2 devastating diseases: adult T-cell leukemia/lymphoma (ATL) and a neurological disorder, HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP or, more briefly, HAM). ATL becomes apparent in 2% to 5% of those infected with HTLV-1; another 1% to 2% will develop HAM. There are usually 2 to 3 decades of latency after the infection before the onset of symptoms. A second HTLV (HTLV-2) isolated in 1982 has been causally linked to HAM, but not ATL...

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