Universidad Peruana Cayetano Heredia

Reducing the global burden of HTLV-1 infection: An agenda for research and action

Reducing the global burden of HTLV-1 infection: An agenda for research and action

Willems, Luc; Hasegawa, Hideki; Accolla, Roberto; Bangham, Charles; Bazarbachi, Ali; Bertazzoni, Umberto; Carneiro-Proietti, Anna Barbara de Freitas; Cheng, Hua; Chieco-Bianchi, Luigi; Ciminale, Vincenzo; Coelho-dos-Reis, Jordana; Esparza, José; Gallo, Robert C.; Gessain, Antoine; Gotuzzo Herencia, José Eduardo; Hall, William; Harford, Joseph; Hermine, Olivier; Jacobson, Steven; Macchi, Beatrice; Macpherson, Calum; Mahieux, Renaud; Matsuoka, Masao; Murphy, Edward; Peloponese, Jean-Marie; Simon, Viviana; Tagaya, Yutaka; Taylor, Graham P.; Watanabe, Toshiki; Yamano, Yoshihisa
URI: https://hdl.handle.net/20.500.12866/6514
Fecha: 2017

Resumen:

Even though an estimated 10–20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has been made to reduce its prevalence. In response to this situation, the Global Virus Network launched a taskforce in 2014 to develop new methods of prevention and treatment of HTLV-1 infection and promote basic research. HTLV-1 is the etiological agent of two life-threatening diseases, adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis, for which no effective therapy is currently available. Although the modes of transmission of HTLV-1 resemble those of the more familiar HIV-1, routine diagnostic methods are generally unavailable to support the prevention of new infections. In the present article, the Taskforce proposes a series of actions to expand epidemiological studies; increase research on mechanisms of HTLV-1 persistence, replication and pathogenesis; discover effective treatments; and develop prophylactic and therapeutic vaccines.

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