DSpace Repository
The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives
- DSpace Home
- →
- Artículos
- →
- Editados por otras instituciones
- →
- Artículos en revistas indizadas
- →
- View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.
The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives
Stembridge, Mike; Williams, Alexandra M.; Gasho, Christopher; Dawkins, Tony G.; Drane, Aimee; Villafuerte, Francisco C.; Levine, Benjamin D.; Shave, Rob; Ainslie, Philip N.
Date:
2019
Abstract:
In contrast to Andean natives, high-altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity. Decades of physiological and genomic research have assumed that the lower hemoglobin concentration in Himalayan natives results from a blunted erythropoietic response to hypoxia (i.e., no increase in total hemoglobin mass). In contrast, herein we test the hypothesis that the lower hemoglobin concentration is the result of greater plasma volume, rather than an absence of increased hemoglobin production. We assessed hemoglobin mass, plasma volume and blood volume in lowlanders at sea level, lowlanders acclimatized to high altitude, Himalayan Sherpa, and Andean Quechua, and explored the functional relevance of volumetric hematological measures to exercise capacity. Hemoglobin mass was highest in Andeans, but also was elevated in Sherpa compared with lowlanders. Sherpa demonstrated a larger plasma volume than Andeans, resulting in a comparable total blood volume at a lower hemoglobin concentration. Hemoglobin mass was positively related to exercise capacity in lowlanders at sea level and in Sherpa at high altitude, but not in Andean natives. Collectively, our findings demonstrate a unique adaptation in Sherpa that reorientates attention away from hemoglobin concentration and toward a paradigm where hemoglobin mass and plasma volume may represent phenotypes with adaptive significance at high altitude.
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||
This item appears in the following Collection(s)
-
Artículos en revistas indizadas [4988]
Recuperados de bases de datos bibliográficas
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess
Related items
Showing items related by title, author, creator and subject.
-
Gonzales Rengifo, Gustavo Francisco; Tapia Aguirre, Vilma Lucrecia; Gasco Tantachuco, Manuel Enrique; Carrillo, C.E. (Taylor and Francis, 2012)Objective: To identify associations of maternal hemoglobin (Hb) with perinatal outcomes at low and moderate altitudes in Peru. Methods: Study of records with sequential information using perinatal database system. The study ...
-
Danaei, G.; Fahimi, S.; Lu, Y.; Zhou, B.; Hajifathalian, K.; Cesare, M.D.; Lo, W.-C.; Reis-Santos, B.; Cowan, M.J.; Shaw, J.E.; Bentham, J.; Lin, J.K.; Bixby, H.; Magliano, D.; Bovet, P.; Miranda, J. Jaime; Khang, Y.-H.; Stevens, G.A.; Riley, L.M.; Ali, M.K.; Ezzati, M.; Kadir, K.A.; Abu-Rmeileh, N.M.; Acosta-Cazares, B.; Aekplakorn, W.; Aguilar-Salinas, C.A.; Ahmadvand, A.; Nsour, M.A.; Alkerwi, A.; Amouyel, P.; Andersen, L.B.; Anderssen, S.A.; Andrade, Dolores S.; Anjana, R.M.; Aounallah-Skhiri, H.; Aris, T.; Arlappa, N.; Arveiler, D.; Assah, F.K.; Avdicová, M.; Balakrishna, N.; Bandosz, P.; Barbagallo, C.M.; Alberto Barceló; Batieha, A.M.; Baur, L.A.; Romdhane, H.B.; Bernabé Ortiz, Antonio; Bhargava, S.K.; Bi, Y.; Bjerregaard, P.; Björkelund, C.; Blake, M.; Blokstra, A.; Bo, S.; Boehm, B.O.; Boissonnet, C.P.; Brajkovich, I.; Breckenkamp, J.; Brewster, L.M.; Brian, G.R.; Bruno, G.; Bugge, A.; de León, A.C.; Can, G.; Cândido, A.P.C.; Capuano, V.; Carvalho, M.J.; Casanueva, F.F.; Caserta, C.A.; Castetbon, K.; Chamukuttan, S.; Chaturvedi, N.; Chen, C.J.; Chen, F.; Chen, S.; Cheng, C.-Y.; Chetrit, A.; Chiou, S.-T.; Cho, Y.; Chudek, J.; Cifkova, R.; Claessens, F.; Concin, H.; Cooper, C.; Cooper, R.; Costanzo, S.; Cottel, D.; Cowell, C.; Crujeiras, A.B.; D'Arrigo, G.; Dallongeville, J.; Dankner, R.; Dauchet, L.; de Gaetano, G.; de Henauw, S.; Deepa, M.; Dehghan, A.; Dhana, K.; Di Castelnuovo, A.F.; Djalalinia, S.; Doua, K.; Drygas, W.; Du, Y.; Egbagbe, E.E.; Eggertsen, R.; Ati, J.E.; Elosua, R.; Erasmus, R.T.; Erem, C.; Ergor, G.; Eriksen, L.; Escobedo-de la Peña, J.; Fall, C.H.; Farzadfar, F.; Felix-Redondo, F.J.; Ferguson, T.S.; Fernández-Bergés, D.; Ferrari, M.; Ferreccio, C.; Finn, J.D.; Föger, B.; Foo, L.H.; Fouad, H.M.; Francis, D.K.; do Carmo Franco, M.; Franco, O.H.; Frontera, G.; Furusawa, T.; Gaciong, Z.; Galbarczyk, A.; Garnett, S.P.; Gaspoz, J.-M.; Gasull, M.; Gates, L.; Geleijnse, J.M.; Ghasemain, A.; Giampaoli, S.; Gianfagna, F.; Giovannelli, J.; Gross, M.G.; González Rivas, J.P.; Gorbea, M.B.; Gottrand, F.; Grant, J.F.; Grodzicki, T.; Grøntved, A.; Gruden, G.; Gu, D.; Guan, O.P.; Guerrero, R.; Guessous, I.; Guimaraes, A.L.; Gutierrez, L.; Hardy, R.; Kumar, R.H.; He, J.; Heidemann, C.; Hihtaniemi, I.T.; Ho, S.Y.; Ho, S.C.; Hofman, A.; Russo Horimoto, A.R.V.; Hormiga, C.M.; Horta, B.L.; Houti, L.; Hussieni, A.S.; Huybrechts, I.; Hwalla, N.; Iacoviello, L.; Iannone, A.G.; Ibrahim, M.M.; Ikeda, N.; Ikram, A.M.; Irazola, V.E.; Islam, M.; Iwasaki, M.; Jacobs, J.M.; Jafar, T.; Jasienska, G.; Jiang, C.Q.; Jonas, J.B.; Joshi, P.; Kafatos, A.; Kalter-Leibovici, O.; Kasaeian, A.; Katz, J.; Kaur, P.; Kavousi, M.; Kelishadi, R.; Kengne, A.P.; Kersting, M.; Khader, Y.S.; Kiechl, S.; Kim, J.; Kiyohara, Y.; Kolsteren, P.; Korrovits, P.; Koskinen, S.; Kratzer, W.; Kromhout, D.; Kula, K.; Kurjata, P.; Kyobutungi, C.; Lachat, C.; Laid, Y.; Lam, T.H.; Landrove, O.; Lanska, V.; Lappas, G.; Laxmaiah, A.; Leclercq, C.; Lee, J.; Lee, J.; Lehtimäki, T.; Rampal, L.; León-Muñoz, L.M.; Li, Y.; Lim, W.-Y.; Fernanda Lima-Costa, M.; Lin, H.-H.; Lin, X.; Lissner, L.; Lorbeer, R.; Lozano, J.E.; Lundqvist, A.; Lytsy, P.; Ma, G.; Machado-Coelho, G.L.L.; Machi, S.; Maggi, S.; Makdisse, M.; Rao, K.M.; Manios, Y.; Manzato, E.; Margozzini, P.; Marques-Vidal, P.; Martorell, R.; Masoodi, S.R.; Matsha, T.E.; Mbanya, J.C.N.; McFarlane, S.R.; McGarvey, S.T.; McLachlan, S.; McNulty, B.A.; Mediene-Benchekor, S.; Meirhaeghe, A.; Menezes, A.M.B.; Merat, S.; Meshram, I.I.; Mi, J.; Miquel, J.F.; Mohamed, M.K.; Mohammad, K.; Mohan, V.; Yusoff, M.F.M.; Moller, N.C.; Molnar, D.; Mondo, C.K.; Moreno, L.A.; Morgan, K.; Moschonis, G.; Mossakowska, M.; Mostafa, A.; Mota, J.; Muiesan, M.L.; Müller-Nurasyid, M.; Mursu, J.; Nagel, G.; Namesna, J.; Nang, E.E.K.; Nangia, V.B.; Navarrete-Muñoz, E.M.; Ndiaye, N.C.; Nervi, F.; Nguyen, N.D.; Nieto-Martínez, R.E.; Ning, G.; Ninomiya, T.; Noale, M.; Noto, D.; Ochoa-Avilés, A.M.; Oh, K.; Onat, A.; Osmond, C.; Otero, J.A.; Palmieri, L.; Panda-Jonas, S.; Panza, F.; Parsaeian, M.; Peixoto, S.V.; Pereira, A.C.; Peters, A.; Peykari, N.; Pilav, A.; Pitakaka, F.; Piwonska, A.; Piwonski, J.; Plans-Rubió, P.; Porta, M.; Portegies, M.L.P.; Poustchi, H.; Pradeepa, R.; Price, J.F.; Punab, M.; Qasrawi, R.F.; Qorbani, M.; Raitakari, O.; Rao, S.R.; Ramachandran, A.; Ramos, R.; Rampal, S.; Rathmann, W.; Redon, J.; Reganit, P.F.M.; Rigo, F.; Robinson, S.M.; Robitaille, C.; Rodríguez, L.A.; Rodríguez-Artalejo, F.; Rodriguez-Perez, M.D.C.; Rojas-Martinez, R.; Romaguera, D.; Rosengren, A.; Rubinstein, A.; Rui, O.; Ruiz-Betancourt, B.S.; Rutkowski, M.; Sabanayagam, C.; Sachdev, H.S.; Saidi, O.; Sakarya, S.; Salanave, B.; Salonen, J.T.; Salvetti, M.; Sánchez-Abanto, J.; dos Santos, R.N.; Santos, R.; Sardinha, L.B.; Scazufca, M.; Schargrodsky, H.; Scheidt-Nave, C.; Shibuya, K.; Shin, Y.; Shiri, R.; Siantar, R.; Sibai, A.M.; Simon, M.; Simons, J.; Simons, L.A.; Sjostrom, M.; Slowikowska-Hilczer, J.; Slusarczyk, P.; Smeeth, L.; Snijder, M.B.; Solfrizzi, V.; Sonestedt, E.; Soumare, A.; Staessen, J.A.; Steene-Johannessen, J.; Stehle, P.; Stein, A.D.; Stessman, J.; Stöckl, D.; Stokwiszewski, J.; Strufaldi, M.W.; Sun, C.-A.; Sundström, J.; Suriyawongpaisal, P.; Sy, R.G.; Tai, E.S.; Tarawneh, M.; Tarqui-Mamani, C.B.; Thijs, L.; Tolstrup, J.S.; Topbas, M.; Torrent, M.; Traissac, P.; Trinh, O.T.H.; Tulloch-Reid, M.K.; Tuomainen, T.-P.; Turley, M.L.; Tzourio, C.; Ueda, P.; Ukoli, F.M.; Ulmer, H.; Valdivia, G.; van Valkengoed, I.G.M.; Vanderschueren, D.; Vanuzzo, D.; Vega, T.; Velasquez-Melendez, G.; Veronesi, G.; Verschuren, M.; Vioque, J.; Virtanen, J.; Visvikis-Siest, S.; Viswanathan, B.; Vollenweider, P.; Voutilainen, S.; Wade, A.N.; Wagner, A.; Walton, J.; Mohamud, W.N.W.; Wang, M.-D.; Wang, Y.X.; Wannamethee, S.G.; Weerasekera, D.; Whincup, P.H.; Widhalm, K.; Wiecek, A.; Wilks, R.J.; Willeit, J.; Wojtyniak, B.; Wong, T.Y.; Woo, J.; Woodward, M.; Wu, A.G.; Wu, F.C.; Wu, S.L.; Xu, H.; Yang, X.; Ye, X.; Yoshihara, A.; Younger-Coleman, N.O.; Zambon, S.; Zargar, A.H.; Zdrojewski, T.; Zhao, W.; Zheng, Y. (Elsevier, 2015)Background: Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the effect of different ...
-
Miranda, J. Jaime; Bernabé Ortiz, Antonio; Stanojevic, S.; Málaga Rodríguez, Germán Javier; Gilman, Robert Hugh; Smeeth, L. (Public Library of Science, 2011)Objectives: To determine the prevalence of type 2 diabetes mellitus, in three groups of Peruvian adults, using fasting glucose and glycosylated hemoglobin (A1C). Methodology/Principal Findings: This study included adults ...
Search DSpace
Browse
-
All of DSpace
-
This Collection
