DSpace Repository

The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives

Show simple item record

dc.contributor.author Stembridge, Mike
dc.contributor.author Williams, Alexandra M.
dc.contributor.author Gasho, Christopher
dc.contributor.author Dawkins, Tony G.
dc.contributor.author Drane, Aimee
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Levine, Benjamin D.
dc.contributor.author Shave, Rob
dc.contributor.author Ainslie, Philip N.
dc.date.accessioned 2019-08-08T15:23:47Z
dc.date.available 2019-08-08T15:23:47Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7163
dc.description.abstract In contrast to Andean natives, high-altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity. Decades of physiological and genomic research have assumed that the lower hemoglobin concentration in Himalayan natives results from a blunted erythropoietic response to hypoxia (i.e., no increase in total hemoglobin mass). In contrast, herein we test the hypothesis that the lower hemoglobin concentration is the result of greater plasma volume, rather than an absence of increased hemoglobin production. We assessed hemoglobin mass, plasma volume and blood volume in lowlanders at sea level, lowlanders acclimatized to high altitude, Himalayan Sherpa, and Andean Quechua, and explored the functional relevance of volumetric hematological measures to exercise capacity. Hemoglobin mass was highest in Andeans, but also was elevated in Sherpa compared with lowlanders. Sherpa demonstrated a larger plasma volume than Andeans, resulting in a comparable total blood volume at a lower hemoglobin concentration. Hemoglobin mass was positively related to exercise capacity in lowlanders at sea level and in Sherpa at high altitude, but not in Andean natives. Collectively, our findings demonstrate a unique adaptation in Sherpa that reorientates attention away from hemoglobin concentration and toward a paradigm where hemoglobin mass and plasma volume may represent phenotypes with adaptive significance at high altitude. en_US
dc.language.iso eng
dc.publisher National Academy of Sciences
dc.relation.ispartofseries Proceedings of the National Academy of Sciences of the United States of America
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adaptation en_US
dc.subject adult en_US
dc.subject altitude en_US
dc.subject Altitude en_US
dc.subject Andean natives en_US
dc.subject Andeans en_US
dc.subject Article en_US
dc.subject blood oxygen tension en_US
dc.subject blood volume en_US
dc.subject body height en_US
dc.subject body mass en_US
dc.subject correlational study en_US
dc.subject hematocrit en_US
dc.subject hematological parameters en_US
dc.subject hemoglobin en_US
dc.subject Hemoglobin en_US
dc.subject hemoglobin determination en_US
dc.subject hemoglobin mass en_US
dc.subject hemoglobin synthesis en_US
dc.subject human en_US
dc.subject human experiment en_US
dc.subject hypoxia en_US
dc.subject Hypoxia en_US
dc.subject indigenous people en_US
dc.subject male en_US
dc.subject oxygen consumption en_US
dc.subject phenotype en_US
dc.subject plasma volume en_US
dc.subject priority journal en_US
dc.subject resting heart rate en_US
dc.subject sea level en_US
dc.subject Sherpa natives en_US
dc.subject Tibetans en_US
dc.title The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1073/pnas.1909002116
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.11
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1091-6490


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics