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Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Nigo, Masayuki; Cevallos, Catalina Salinas; Woods, Krystina; Flores, Vicente Maco; Francis, Gweneth; Perlman, David C.; Revuelta, Manuel; Mildvan, Donna; Waldron, Mary; Gomez, Tessa; Koshy, Sanjana; Jodlowski, Tomasz; Riley, William; Ruhe, Jorg J.
URI: https://hdl.handle.net/20.500.12866/10377
Date: 2013

Abstract:

We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P = 0.002) was the only independent predictor of subsequent isolation of a TR strain.

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