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Association between Human Papillomavirus and Human T-Lymphotropic Virus in Indigenous Women from the Peruvian Amazon

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dc.contributor.author Blas Blas, Magaly Marlitz
dc.contributor.author Alva, I.E.
dc.contributor.author Garcia Funegra, Patricia Jannet
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Montano, S.M.
dc.contributor.author Muñante, R.
dc.contributor.author Zunt, J.R.
dc.date.accessioned 2022-01-18T19:34:39Z
dc.date.available 2022-01-18T19:34:39Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11103
dc.description.abstract Background: No association between the Human T-cell lymphotropic virus (HTLV), an oncogenic virus that alters host immunity, and the Human Papillomavirus (HPV) has previously been reported. Examining the association between these two viruses may permit the identification of a population at increased risk for developing cervical cancer. Methods and Findings: Between July and February , we conducted a cross-sectional study among indigenous Amazonian Peruvian women from the Shipibo-Konibo ethnic group, a group with endemic HTLV infection. We recruited women between 15 and 39 years of age who were living in the cities of Lima and Ucayali. Our objectives were to determine the association between HTLV and: (i) HPV infection of any type, and (ii) high-risk HPV type infection. Sexually active Shipibo-Konibo women were screened for HTLV-1 and HTLV-2 infections. All HTLV-1 or -2 positive women, along with two community-matched HTLV negative sexually active Shipibo-Konibo controls were later tested for the presence of HPV DNA, conventional cytology, and HIV. We screened 1,253 Shipibo-Konibo women, observing a prevalence of 5.9% (n = 74) for HTLV-1 and 3.8% (n = 47) for HTLV-2 infections. We enrolled 62 (60.8%) HTLV-1 positive women, 40 (39.2%) HTLV-2 positive women, and 205 community-matched HTLV negative controls. HTLV-1 infection was strongly associated with HPV infection of any type (43.6% vs. 29.3%; Prevalence Ratio (PR): 2.10, 95% CI: 1.53-2.87), and with high-risk HPV infection (32.3% vs. 22.4%; PR: 1.93, 95% CI: 1.04-3.59). HTLV-2 was not significantly associated with either of these HPV infections. Conclusions: HTLV-1 infection was associated with HPV infection of any type and with high-risk HPV infection. Future longitudinal studies are needed to evaluate the incidence of high-risk HPV infection as well as the incidence of cervical neoplasia among HTLV-1 positive women. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Young Adult en_US
dc.subject article en_US
dc.subject controlled study en_US
dc.subject cross-sectional study en_US
dc.subject major clinical study en_US
dc.subject endemic disease en_US
dc.subject disease association en_US
dc.subject Prevalence en_US
dc.subject Sexual Behavior en_US
dc.subject Human immunodeficiency virus en_US
dc.subject HTLV-I Infections en_US
dc.subject Human T cell leukemia virus 1 en_US
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject human cell en_US
dc.subject indigenous people en_US
dc.subject cytology en_US
dc.subject Ethnic Groups en_US
dc.subject infection risk en_US
dc.subject urban area en_US
dc.subject laboratory test en_US
dc.subject HTLV-II Infections en_US
dc.subject Human T cell leukemia virus 2 en_US
dc.subject Population Groups en_US
dc.subject Papillomavirus Infections en_US
dc.subject DNA determination en_US
dc.subject high risk patient en_US
dc.subject virus infection en_US
dc.subject Wart virus en_US
dc.subject Human papillomavirus en_US
dc.subject Papillomaviridae en_US
dc.subject virus DNA en_US
dc.subject Human T-lymphotropic virus 2 en_US
dc.subject Amazonian Peruvian en_US
dc.subject community sample en_US
dc.subject Human T lymphotropic virus 1 infection en_US
dc.subject Human T lymphotropic virus 2 infection en_US
dc.subject Shipibo Konibo ethnic group en_US
dc.title Association between Human Papillomavirus and Human T-Lymphotropic Virus in Indigenous Women from the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0044240
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1932-6203


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