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Reducing the global burden of HTLV-1 infection: An agenda for research and action

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dc.contributor.author Willems, Luc
dc.contributor.author Hasegawa, Hideki
dc.contributor.author Accolla, Roberto
dc.contributor.author Bangham, Charles
dc.contributor.author Bazarbachi, Ali
dc.contributor.author Bertazzoni, Umberto
dc.contributor.author Carneiro-Proietti, Anna Barbara de Freitas
dc.contributor.author Cheng, Hua
dc.contributor.author Chieco-Bianchi, Luigi
dc.contributor.author Ciminale, Vincenzo
dc.contributor.author Coelho-dos-Reis, Jordana
dc.contributor.author Esparza, José
dc.contributor.author Gallo, Robert C.
dc.contributor.author Gessain, Antoine
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Hall, William
dc.contributor.author Harford, Joseph
dc.contributor.author Hermine, Olivier
dc.contributor.author Jacobson, Steven
dc.contributor.author Macchi, Beatrice
dc.contributor.author Macpherson, Calum
dc.contributor.author Mahieux, Renaud
dc.contributor.author Matsuoka, Masao
dc.contributor.author Murphy, Edward
dc.contributor.author Peloponese, Jean-Marie
dc.contributor.author Simon, Viviana
dc.contributor.author Tagaya, Yutaka
dc.contributor.author Taylor, Graham P.
dc.contributor.author Watanabe, Toshiki
dc.contributor.author Yamano, Yoshihisa
dc.date.accessioned 2019-04-25T15:46:34Z
dc.date.available 2019-04-25T15:46:34Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/6514
dc.description.abstract Even though an estimated 10–20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has been made to reduce its prevalence. In response to this situation, the Global Virus Network launched a taskforce in 2014 to develop new methods of prevention and treatment of HTLV-1 infection and promote basic research. HTLV-1 is the etiological agent of two life-threatening diseases, adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis, for which no effective therapy is currently available. Although the modes of transmission of HTLV-1 resemble those of the more familiar HIV-1, routine diagnostic methods are generally unavailable to support the prevention of new infections. In the present article, the Taskforce proposes a series of actions to expand epidemiological studies; increase research on mechanisms of HTLV-1 persistence, replication and pathogenesis; discover effective treatments; and develop prophylactic and therapeutic vaccines. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Antiviral Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Human immunodeficiency virus vaccine en_US
dc.subject disease course en_US
dc.subject disease transmission en_US
dc.subject HTLV-1 infection en_US
dc.subject human en_US
dc.subject human T cell leukemia virus en_US
dc.subject pathogenesis en_US
dc.subject prediction en_US
dc.subject priority journal en_US
dc.subject research priority en_US
dc.subject Review en_US
dc.subject T cell leukemia en_US
dc.subject tropical spastic paraparesis en_US
dc.subject advisory committee en_US
dc.subject cost of illness en_US
dc.subject global health en_US
dc.subject HTLV-1 infection en_US
dc.subject Human immunodeficiency virus infection en_US
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject isolation and purification en_US
dc.subject medical research en_US
dc.subject spinal cord disease en_US
dc.subject transmission en_US
dc.subject tropical spastic paraparesis en_US
dc.subject virology en_US
dc.subject Advisory Committees en_US
dc.subject Biomedical Research en_US
dc.subject Cost of Illness en_US
dc.subject Global Health en_US
dc.subject HIV Infections en_US
dc.subject HTLV-I Infections en_US
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject Humans en_US
dc.subject Leukemia-Lymphoma, Adult T-Cell en_US
dc.subject Paraparesis, Tropical Spastic en_US
dc.subject Spinal Cord Diseases en_US
dc.title Reducing the global burden of HTLV-1 infection: An agenda for research and action en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1016/j.antiviral.2016.10.015
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1872-9096

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