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Nitric oxide and superoxide anion balance in rats exposed to chronic and long term intermittent hypoxia

Nitric oxide and superoxide anion balance in rats exposed to chronic and long term intermittent hypoxia

Siques, Patricia; Lopez de Pablo, Angel Luis; Brito, Julio; Arribas, Silvia M.; Flores, Karen; Arriaza, Karem; Naveas, Nelson; Gonzalez, M. Carmen; Hoorntje, Alexander; León-Velarde, Fabiola; Lopez, M. Rosario
URI: https://hdl.handle.net/20.500.12866/7988
Date: 2014

Abstract:

Work at high altitude in shifts exposes humans to a new form of chronic intermittent hypoxia, with still unknown health consequences. We have established a rat model resembling this situation, which develops a milder form of right ventricular hypertrophy and pulmonary artery remodelling compared to continuous chronic exposure. We aimed to compare the alterations in pulmonary artery nitric oxide (NO) availability induced by these forms of hypoxia and the mechanisms implicated. Rats were exposed for 46 days to normoxia or hypobaric hypoxia, either continuous (CH) or intermittent (2 day shifts, CIH2x2), and assessed: NO and superoxide anion availability (fluorescent indicators and confocal microscopy); expression of phosphorylated endothelial NO synthase (eNOS).

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info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

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